Data on metabolic profile of insulin-degrading enzyme knockout mice

Diego O. Borges; Maria João Meneses; Tânia R. Dias; Fátima O. Martins; Pedro F. Oliveira; Marco G. Alves; M. Paula Macedo

doi:10.1016/j.dib.2019.104023

Data on metabolic profile of insulin-degrading enzyme knockout mice

Diego O. Borges, Maria João Meneses, Tânia R. Dias, Fátima O. Martins, Pedro F. Oliveira, Marco G. Alves, M. Paula Macedo

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Abstract

Insulin-degrading enzyme (IDE) degrades and inactivates bioactive peptides such as insulin. As insulin is a master regulator of glucose homeostasis, lack of IDE is expected to have a profound impact on both insulin and glucose levels. This article shares data on glucose and insulin homeostasis of control, heterozygous and knockout mice for Ide after 18 weeks of a normal chow diet. This data article is related to a research article entitled “Knockout of insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality” (Meneses et al., 2019).

Original language	English
Article number	104023
Journal	Data in brief
Volume	25
DOIs	https://doi.org/10.1016/j.dib.2019.104023
Publication status	Published - 1 Aug 2019

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10.1016/j.dib.2019.104023Licence: CC BY

1-s2.0-S2352340919303762-mainFinal published version, 395 KBLicence: CC BY

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title = "Data on metabolic profile of insulin-degrading enzyme knockout mice",

abstract = "Insulin-degrading enzyme (IDE) degrades and inactivates bioactive peptides such as insulin. As insulin is a master regulator of glucose homeostasis, lack of IDE is expected to have a profound impact on both insulin and glucose levels. This article shares data on glucose and insulin homeostasis of control, heterozygous and knockout mice for Ide after 18 weeks of a normal chow diet. This data article is related to a research article entitled “Knockout of insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality” (Meneses et al., 2019).",

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AU - Borges, Diego O.

AU - Meneses, Maria João

AU - Dias, Tânia R.

AU - Martins, Fátima O.

AU - Oliveira, Pedro F.

AU - Alves, Marco G.

AU - Macedo, M. Paula

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Data on metabolic profile of insulin-degrading enzyme knockout mice

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