Exploring the origin and degree of genetic isolation of Anopheles gambiae from the islands of São Tomé and Príncipe, potential sites for testing transgenic-based vector control

Jonathon C. Marshall, João Pinto, Jacques Derek Charlwood, Gabriele Gentile, Federica Santolamazza, FrèDèRic R. Simard, Alessandra Della Torre, Martin J. Donnelly, Adalgisa Caccone

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The evolutionary processes at play between island and mainland populations of the malaria mosquito vector Anopheles gambiae sensu stricto are of great interest as islands may be suitable sites for preliminary application of transgenic-based vector control strategies. S˜o Tom´ and Príncipe, located off the West African coast, have received such attention in recent years. This study investigates the degree of isolation of An. gambiae s.s. populations between these islands and the mainland based on mitochondrial and ribosomal DNA molecular data. We identify possible continental localities from which these island populations derived. For these purposes, we used FST values, haplotype networks, and nested clade analysis to estimate migration rates and patterns. Haplotypes from both markers are geographically widespread across the African continent. Results indicate that the populations from Sa˜o Tome´ and Prı´ncipe are relatively isolated from continental African populations, suggesting they are promising sites for test releases of transgenic individuals. These island populations are possibly derived from two separate continental migrations. This result is discussed in the context of the history of the African slave trade with respect to São Tomé and Príncipe.

Original languageEnglish
Pages (from-to)631-644
Number of pages14
JournalEvolutionary Applications
VolumeVol. 1
Issue numbern.º 4
DOIs
Publication statusPublished - Nov 2008

Keywords

  • Anopheles gambiae
  • Island colonization
  • Malaria
  • Mitochondrial DNA
  • Phylogeography
  • Ribosomal DNA

UN Sustainable Development Goals (SDGs)

  • SDG 3 - Good Health and Well-Being
  • SDG 15 - Life on Land

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