TY - JOUR
T1 - First description of colistin and tigecycline-resistant acinetobacter baumannii producing KPC-3 carbapenemase in Portugal
AU - Caneiras, Cátia
AU - Calisto, Filipa
AU - da Silva, Gabriela Jorge
AU - Lito, Luis
AU - Melo-Cristino, José
AU - Duarte, Aida
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.
AB - Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.
KW - A. Baumannii
KW - Antimicrobial resistance
KW - Colistin
KW - Gram-negative bacteria
KW - K. Pneumoniae
KW - KPC-3 carbapenemase
KW - Tigecycline
UR - http://www.scopus.com/inward/record.url?scp=85057153523&partnerID=8YFLogxK
U2 - 10.3390/antibiotics7040096
DO - 10.3390/antibiotics7040096
M3 - Article
AN - SCOPUS:85057153523
VL - 7
JO - Antibiotics (Basel, Switzerland)
JF - Antibiotics (Basel, Switzerland)
SN - 2079-6382
IS - 4
M1 - 96
ER -