Influence of poly(N-isopropylacrylamide) and poly(N,N′-diethyl acrylamide) coatings on polysulfone/polyacrylonitrile-based membranes for protein separation

Telma Barroso, Raquel Viveiros, Margarida Coelho, Teresa Casimiro, Ana M. Botelho do Rego, Ana Aguiar-Ricardo

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Herein we describe the design and the assembly of temperature sensitive polysulfone (PS)/polyacrylonitrile (PAN) blend membranes using supercritical fluid technology. Blended membranes were prepared using the CO 2-assisted phase inversion method, and their pores were coated with two thermoresponsive hydrogels-poly(N-isopropylacrylamide) (PNIPAAm) and poly(N,N′-diethylacrylamide) (PDEAAm). Permeation experiments of bovine serum albumin (BSA) and lysozyme (LYS) solutions were used to evaluate the performance and temperature-responsive behavior of coated membranes. While membranes coated with PNIPAAm presented similar protein permeation profiles at temperatures below and above its lower critical solution temperature, PDEAAm coating imparted a temperature-responsive behavior to PS/PAN (90:10) membranes and selective permeation of proteins with different sizes.

Original languageEnglish
Pages (from-to)1381-1393
Number of pages13
JournalPolymers For Advanced Technologies
Volume23
Issue number10
DOIs
Publication statusPublished - 1 Oct 2012

Keywords

  • Hydrogels
  • Protein filtration
  • Supercritical carbon dioxide
  • Thermoresponsive membranes

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