Iron Homeostasis in Health and Disease

Raffaella Gozzelino, Paolo Arosio

Research output: Contribution to journalReview articlepeer-review

118 Citations (Scopus)

Abstract

Iron is required for the survival of most organisms, including bacteria, plants, and humans. Its homeostasis in mammals must be fine-tuned to avoid iron deficiency with a reduced oxygen transport and diminished activity of Fe-dependent enzymes, and also iron excess that may catalyze the formation of highly reactive hydroxyl radicals, oxidative stress, and programmed cell death. The advance in understanding the main players and mechanisms involved in iron regulation significantly improved since the discovery of genes responsible for hemochromatosis, the IRE/IRPs machinery, and the hepcidin-ferroportin axis. This review provides an update on the molecular mechanisms regulating cellular and systemic Fe homeostasis and their roles in pathophysiologic conditions that involve alterations of iron metabolism, and provides novel therapeutic strategies to prevent the deleterious effect of its deficiency/overload.
Original languageEnglish
Article number130
JournalInternational Journal of Molecular Sciences
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 2016

Keywords

  • iron metabolism
  • iron toxicity
  • iron

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