Metal Free Synthesis of Secondary Arylamines: An Aliphatic to Aromatic Transformation

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Abstract

An efficient method for the N‐arylation of primary and some secondary amines using 2‐halocyclohex‐2‐enones in an aliphatic‐to‐aromatic transformation in the presence of a substoichiometric amount of pTsOH has been developed. A series of arylamines have been synthesized from 2‐halocyclohex‐2‐enones by in situ enamine formation followed by aromatization under environmentally friendly conditions using pTsOH. This metal‐free, practical, relatively inexpensive protocol is of value in organic synthesis for industrial and academic applications.
Original languageEnglish
Pages (from-to)742-747
JournalEuropean Journal of Organic Chemistry
Issue number4
DOIs
Publication statusPublished - 1 Feb 2013

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