Proximal Nerve Root Involvement in immunoglobulin M Anti-Myelin-Associated Glycoprotein Neuropathy Presenting as Cauda Equina Syndrome

Marco Fernandes, Pedro Calvão-Pires, André Caetano, Luís Santos

Research output: Contribution to journalArticlepeer-review

Abstract

Typical distal symptoms in anti-myelin-associated glycoprotein (anti-MAG) neuropathy are believed to be due to the binding of immunoglobulin M to distal nerve terminals. We describe the case of a 56-year-old man diagnosed with immunoglobulin M anti-MAG neuropathy in the setting of Waldenström macroglobulinemia, which developed acute neurological worsening presenting as cauda equina syndrome. Lumbosacral magnetic resonance imaging revealed enlarged nerve roots with diffuse heterogeneous gadolinium enhancement. Treatment with steroids resulted in substantial clinical improvement. Increased recognition of atypical presentations may lead to improved characterization of anti-MAG neuropathy as a more widespread disease.

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalJournal of clinical neuromuscular disease
Volume22
Issue number2
DOIs
Publication statusPublished - 1 Dec 2020

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