Stereochemical effects in the metabolic activation of nitrosopiperidines: Correlations with genotoxicity

Samuel González-Mancebo, Jorge Gaspar, Emilio Calle, Sónia Pereira, Ana Mariano, José Rueff, Julio Casado

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The genotoxicity of nitrosopiperidine and six alkyl derivatives was studied by use of the Ames tester strains TA100 and TA1535 in the pre-incubation method. Among the compounds investigated, those exhibiting genotoxic activity under the experimental conditions employed were only genotoxic in the presence of S9 mix (10%). The results obtained were correlated with models of the metabolic activation of nitrosamines in an attempt to rationalize the genotoxicity of these compounds. The results show that the presence of substituents in the nitrosopiperidine molecule may be one of the modulating factors affecting the genotoxicity of these cyclic nitrosamines, and may help provide some chemical clues for the identification of risk compounds from among a large group of structurally related molecules.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume558
Issue number1-2
DOIs
Publication statusPublished - 14 Mar 2004

Keywords

  • Genotoxicity of nitrosopiperidines
  • Nitrosamines
  • Nitrosopiperidines
  • Structural effects in metabolic activation

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